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Nano Quantity Analyze Detector for Aerosol Laser Counting Detector
Wide applicability: Almost all non-volatile and semi volatile substances can be detected High sensitivity: up to ng level (1-2 orders of magnitude hig
Product details
Nano Quantity Analyze Detector for Aerosol Laser Counting Detector
- Wide applicability: Almost all non-volatile and semi volatile substances can be detected
- High sensitivity: reaching ng level (1-2 orders of magnitude higher than ELSD)
- Quality responsive type: signal response consistency that relies solely on quality, independent of chemical properties
- The current response range is wide: the dynamic monitoring range can reach 4 orders of magnitude, from ng to µ g
- Excellent environmental stability: almost unaffected by external environmental changes (such as temperature)
- Economic and environmental protection: can use only compressed air or nitrogen gas
- Intuitive operation: touch screen panel operation
- Easy maintenance: only need to replace small parts every six months
- *This device is produced by Osaka Soda Co., Ltd
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characteristic
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application
characteristic
The outstanding performance of NQAD comes from its core component, the Water Condensation Particle Counter (WCPC)
Brief description of the working principle of NQAD:
- The elution solution of the chromatographic column is atomized inside NQAD (①)
- Volatile components are evaporated, and residual components form particle clusters (②)
- Each particle absorbs water vapor, forming a water condensation body, and the droplets increase the particle size to the μ m level (③ - ⑤)
- When each water condensate passes through the detection area, it emits pulsed scattered light under laser irradiation, and counts the pulses (⑥)
To conduct testing
WCPC feature description:
- The droplet size of the test substance increases, the monitoring sensitivity is improved, and the dynamic monitoring range is expanded
- The pulse count value is linearly related to the number of water condensates formed by the test substance
- The response signal value is only related to the quantity of water condensation, that is, it is only related to the mass of the test substance and has nothing to do with the chemical properties of the test substance
application
The Aerosol Laser Counting Detector (NQAD) is suitable for:
- Substances without UV absorption
- Substances that are difficult to ionize
- Substances without electrochemical activity
- Substances with unknown properties
For example: amino acids, sugars, plant medicines, polymers, chemical drugs, esters, cholesterol, ions, surfactants, amines, proteins, etc
The oligomer distribution of polyethylene glycol (PEG, average molecular weight 4000) was determined using CAPCELL CORE MP S2.7 (2.1 mm i.d. x 50 mm). Using NQAD detector, a chromatogram can be obtained to characterize the mass distribution.
【HPLC Conditions】
| Column | CAPCELL CORE MP S2.7 ; 2.1 mm i.d. x 50 mm |
| Mobile phase | A) H2O, B) CH3CN B 20 % (0 min) → 40 % (10 min) → 20 % (10.1 min) |
| Flow rate | 400 µL/min |
| Temperature | 50 ˚C |
| Detector | NQAD (Evaporation 35 ˚C，Nubulizer 30 ˚C，Filter 2.5 s) TOF-MS (ESI positive, MicroTOF, Bruker) |
| Inj. vol | 2 µL |
| Sample dissolved in | 20 % CH3CN * 1 µg/mL = 1 ppm |
For more applications, please feel free to contact us
application
Introduce measurement examples of high-performance liquid chromatography (HPLC) in various fields.
Basic Course on High Performance Liquid Chromatography
Introduce the basic knowledge of high-performance liquid chromatography, including the principles and system composition of high-performance liquid chromatography, as well as the characteristics of various detection methods.
Science Environment
Introduce the symbol of Hitachi High Tech Science Group, which aims to become a leader in the technology field.
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